Characterization of CD34+ hematopoietic cells in systemic mastocytosis: Potential role in disease dissemination.

Andrea MayadoC TeodosioN Dasilva-FreireM Jara-AcevedoA C Garcia-MonteroI Álvarez-TwoseL Sánchez-MuñozA MatitoC CaldasJ I Muñoz-GonzálezA HenriquesJ I Sánchez-GallegoL EscribanoA Orfao

Published in: Allergy (2018)

The presence of the KIT D816V mutation in PB of ISM patients is associated with (early) involvement of circulating CD34+ HPC and multiple myeloid cell subpopulations, KIT-mutated PB CD34+ HPC potentially contributing to early dissemination of the disease.

Keyphrases

heavy metals
end stage renal disease
bone marrow
induced apoptosis
ejection fraction
newly diagnosed
nk cells
single cell
acute myeloid leukemia
stem cells
immune response
endoplasmic reticulum stress
aqueous solution