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RNA-Based Homologous Recombination Deficiency Signature Detects Homologous Recombination Deficiency-RNA+ Patients With and Without Homologous Recombination Repair Gene Pathogenic Alterations in Men With Prostate Cancer.

Landon C BrownJason ZhuElizabeth MauerStephanie N ThiedeLisa MaceraMichelle M SteinTimothy TaxterDerek RaghavanEarle F Burgess
Published in: JCO precision oncology (2023)
Use of an RNA-based HRD signature significantly expands the fraction of patients with prostate cancer who may derive benefit from poly (ADP-ribose) polymerase inhibitors (PARPis) compared with using HRR gene mutations alone. Further studies are needed to evaluate functional HRD significance and inform future usage as a predictive biomarker for PARPi selection.
Keyphrases
  • dna repair
  • prostate cancer
  • dna damage
  • radical prostatectomy
  • oxidative stress
  • copy number
  • replacement therapy
  • gene expression
  • transcription factor