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TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function.

George KotsarisDespoina KerselidouDimitrios KoutsoubarisElena ConstantinouGeorge MalamasDimitrios A GaryfallosEudoxia G Ηatzivassiliou
Published in: Journal of biological research (Thessalonike, Greece) (2020)
Our protein-interaction experiments demonstrated that TRAF3 can interact with GMEB1, which is an inhibitor of apoptosis. In addition, cell viability assays showed that overexpression of TRAF3 enhanced the anti-apoptotic activity of GMEB1, supporting a regulatory role of TRAF3 in GMEB1-mediated inhibition of apoptosis. Better understanding of the molecular mechanism of TRAF3 function will improve diagnostics and targeted therapeutic approaches for TRAF3-associated disorders.
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