Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): The Future of Human and Veterinary Regenerative Medicine.
María Gemma VelascoKatiuska SatuéDeborah ChicharroEmma MartinsMarta TorresPau PeláezLaura Miguel-PastorAyla Del RomeroElena DamiáBelén CuervoJosé María CarrilloRamón CugatJoaquín Jesús SopenaMonica RubioPublished in: Biomedicines (2023)
In recent years, several studies have been conducted on Muse cells mainly due to their pluripotency, high tolerance to stress, self-renewal capacity, ability to repair DNA damage and not being tumoral. Additionally, since these stem cells can be isolated from different tissues in the adult organism, obtaining them is not considered an ethical problem, providing an advantage over embryonic stem cells. Regarding their therapeutic potential, few studies have reported clinical applications in the treatment of different diseases, such as aortic aneurysm and chondral injuries in the mouse or acute myocardial infarction in the swine, rabbit, sheep and in humans. This review aims to describe the characterization of Muse cells, show their biological characteristics, explain the differences between Muse cells and mesenchymal stem cells, and present their contribution to the treatment of some diseases.
Keyphrases
- induced apoptosis
- cell cycle arrest
- stem cells
- dna damage
- mesenchymal stem cells
- acute myocardial infarction
- endothelial cells
- gene expression
- embryonic stem cells
- cell death
- magnetic resonance imaging
- oxidative stress
- signaling pathway
- magnetic resonance
- cell proliferation
- pi k akt
- young adults
- computed tomography
- combination therapy
- heat stress
- atrial fibrillation
- stress induced
- dna repair
- current status
- decision making
- induced pluripotent stem cells