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Association of puberty timing with type 2 diabetes: A systematic review and meta-analysis.

Tuck Seng ChengFelix R DayRajalakshmi LakshmanKen K Ong
Published in: PLoS medicine (2020)
Earlier AAM is consistently associated with higher T2D/IGT risk, independent of adiposity. More importantly, this research has identified that a substantial proportion of T2D in women is related to early menarche, which would be expected to increase in light of global secular trends towards earlier puberty timing. These findings highlight the need to identify the underlying mechanisms linking early menarche to T2D/IGT risk.
Keyphrases
  • polycystic ovary syndrome
  • insulin resistance
  • type diabetes
  • body mass index
  • pregnant women
  • weight gain