3D Breast Tumor Models for Radiobiology Applications.
Akhilandeshwari RavichandranJulien CleggMark Nathaniel AdamsMadison HampsonAndrew FieldingLaura J BrayPublished in: Cancers (2021)
Breast cancer is a leading cause of cancer-associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two-dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three-dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre-clinical 3D models offer in improving our understanding of this treatment modality.
Keyphrases
- radiation therapy
- locally advanced
- cancer therapy
- induced apoptosis
- minimally invasive
- squamous cell carcinoma
- rectal cancer
- radiation induced
- gene expression
- papillary thyroid
- drug delivery
- type diabetes
- polycystic ovary syndrome
- cell proliferation
- young adults
- cell cycle arrest
- childhood cancer
- coronary artery bypass
- endoplasmic reticulum stress
- skeletal muscle
- oxidative stress
- signaling pathway
- insulin resistance
- acute coronary syndrome
- surgical site infection
- breast cancer risk
- lymph node metastasis
- smoking cessation
- replacement therapy