Rapid Total Synthesis of Iheyamine A via a Pictet-Spengler/Redox-Mediated Cyclization Cascade.
Ya WuMing WangMei XuSheng LiuPublished in: The Journal of organic chemistry (2023)
The Pictet-Spengler reaction between tryptamine and (5-methoxy-2-nitrophenyl)-glyoxal in hot AcOH could trigger a redox-mediated cyclization and reduction sequence to form iheyamine A in 52% yield.