Piezoionic strain sensors have attracted enormous attention in artificial skin perception because of high sensitivity, lightweight, and flexibility. However, their sensing properties are limited by a weak material interface based on physical adhesion, which usually leads to fast performance deterioration under mechanical conditions. In this work, a bio-inspired interface has been reported based on an in situ growth strategy and then utilized for piezoionic sensor assembly. The robust coupling interface provides fast kinetic of ion transfer and prevents interface slippage under external strains. The as-fabricated sensors give high sensing voltage with high sensitivity. It delivers excellent cycling stability with performance retention above 90% over thousands of bending cycles in air. Further, the sensors have been explored as an effective platform for skin perception, and many detections can be realized within our devices, such as skin touch, eye movement, cheek bulging, and finger movement.