Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus.
Adrià AteridoAntonio JuliàPatricia CarreiraRicardo BlancoJosé Javier López-LongoJosé Javier Pérez VenegasÀlex OlivéJosé Luís AndreuMaria Ángeles Aguirre-ZamoranoPaloma VelaJoan M NollaJosé Luís Marenco-de la FuenteAntonio ZeaJosé María PegoMercedes FreireElvira DíezMaría López-LasantaMireia López-CorbetoNúria PalauRaül TortosaJosep Lluís GelpíDevin AbsherRichard M MyersAntonio Fernández-NebroSara MarsalPublished in: Arthritis research & therapy (2017)
The present study has identified VEGF genetic pathway association with the risk of oral ulceration in SLE. New therapies targeting the VEGF pathway could be more effective in reducing the severity of this phenotype. These findings represent a first step towards the understanding of the genetic basis of phenotype heterogeneity in SLE.