Endothelial to mesenchymal transition is an active process in smokers and patients with early COPD contributing to pulmonary arterial pathology.
Prem BhattaraiWenying LuAshutosh HardikarSurajit DeyArchana Vijay GaikwadAffan Mahmood ShahzadCollin ChiaAndrew WilliamsGurpreet Kaur SingheraTillie-Louise HackettMathew Suji EapenSukhwinder Singh SohalPublished in: ERJ open research (2024)
This is the first study showing the acquisition of mesenchymal traits by pulmonary endothelial cells from NLFS, SAD and mild-moderate COPD patients through EndMT. This informs on the potential early origins of pulmonary hypertension in smokers and patients with early COPD.
Keyphrases
- pulmonary hypertension
- chronic obstructive pulmonary disease
- endothelial cells
- lung function
- end stage renal disease
- stem cells
- bone marrow
- smoking cessation
- pulmonary artery
- ejection fraction
- newly diagnosed
- pulmonary arterial hypertension
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- cystic fibrosis
- climate change
- high glucose
- human health