Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19.

Dat P HaWoo-Jin ShinZe LiuMichael E DocheRoy LauNektaria Maria LeliCrystal S ConnMariangela RussoAnnalisa LorenzatoConstantinos KoumenisMin YuShannon M MumenthalerAmy S Lee

Published in: Cell & bioscience (2024)

Our findings validate GRP78 as a target of OLN anti-cancer and anti-viral activities. These proof-of-principle studies support further investigation of OLN as a readily accessible compound to dually combat cancer and COVID-19.

Keyphrases

sars cov
coronavirus disease
papillary thyroid
squamous cell
endoplasmic reticulum stress
signaling pathway
lymph node metastasis
heart failure
respiratory syndrome coronavirus
childhood cancer
case control