Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer.
Elias OroujiAyush T RamanAnand K SinghAlexey SorokinEmre ArslanArchit K GhoshJonathan SchulzChristopher TerranovaShan JiangMing TangMayinuer MaitituohetiScot C CallahanPraveen BarrodiaKatarzyna TomczakYingda JiangZhiqin JiangJennifer S DavisSukhen GhoshHey Min LeeLaura Reyes-UribeKyle ChangYusha LiuHuiqin ChenAli AzhdariniaJeffrey MorrisEduardo VilarKendra S CarmonScott E KopetzKunal RaiPublished in: Gut (2021)
Our data suggest that the dynamics of active enhancer underlies CRC progression and the patient-specific enhancer patterns can be leveraged for precision combination therapy.