Login / Signup

Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer.

Elias OroujiAyush T RamanAnand K SinghAlexey SorokinEmre ArslanArchit K GhoshJonathan SchulzChristopher TerranovaShan JiangMing TangMayinuer MaitituohetiScot C CallahanPraveen BarrodiaKatarzyna TomczakYingda JiangZhiqin JiangJennifer S DavisSukhen GhoshHey Min LeeLaura Reyes-UribeKyle ChangYusha LiuHuiqin ChenAli AzhdariniaJeffrey MorrisEduardo VilarKendra S CarmonScott E KopetzKunal Rai
Published in: Gut (2021)
Our data suggest that the dynamics of active enhancer underlies CRC progression and the patient-specific enhancer patterns can be leveraged for precision combination therapy.
Keyphrases
  • combination therapy
  • transcription factor
  • binding protein
  • gene expression
  • dna damage
  • electronic health record
  • genome wide
  • dna methylation
  • machine learning
  • deep learning
  • artificial intelligence
  • data analysis