Micro-diffusely abnormal white matter: An early multiple sclerosis lesion phase with intensified myelin blistering.

Antonio LuchicchiGema Muñoz-GonzalezSaar T HalperinEva StrijbisLaura H M van DijkChrisa FoutiadouFlorence UriacPiet M BoumanMaxime A N SchoutenJason PlemelBert A 't HartJeroen J G GeurtsGeert J Schenk

Published in: Annals of clinical and translational neurology (2024)

We report a new histologically defined early phase in MS lesion formation, namely mDAWM, which lacks signs of Wallerian pathology. These results support the prelesional nature of the mDAWM. We conceptualize that evolution to pathologically evident lesions comprises the previously documented imbalance of axo-myelinic units (myelin blistering) leading to their degeneration and immune system activation by released myelin components.

Keyphrases

white matter
multiple sclerosis
ms ms