Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials.
Benedetta RussoFabiana PicconiIlaria MalandruccoSimona FrontoniPublished in: International journal of molecular sciences (2019)
Insulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this review is to analyse the data observed in vitro, in vivo and in clinical trials concerning the effects of flavonoids on insulin resistance and to determine the molecular mechanisms with which flavonoids interact with insulin signaling.
Keyphrases
- insulin resistance
- metabolic syndrome
- clinical trial
- type diabetes
- adipose tissue
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- glycemic control
- high fat diet induced
- phase ii
- single molecule
- drinking water
- electronic health record
- machine learning
- risk assessment
- artificial intelligence
- human health
- double blind