Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.

Chunmei WangLi CheJunjie HuShanshan ZhangLijie JiangGavinella LatteMaria I DemartisJunyan TaoBing GuiMaria G PiloSilvia RibbackFrank DombrowskiMatthias EvertDiego F CalvisiXin Chen

Published in: Liver international : official journal of the International Association for the Study of the Liver (2016)

Both H1047R and E545K are able to activate the AKT/mTOR pathway. An intact AKT2/mTOR complex 1 cascade is required for tumourigenesis induced by H1047R/c-Met or E545K/c-Met in the liver.

Keyphrases

cell proliferation
signaling pathway
tyrosine kinase
wild type
high fat diet induced
type diabetes
metabolic syndrome
skeletal muscle
insulin resistance