Association Between the Intracellular Tacrolimus Concentration in CD3 + T Lymphocytes and CD14 + Monocytes and Acute Kidney Transplant Rejection.

Suwasin UdomkarnjananunMarith I FranckeMarjolein DieterichDaan van de VeldeJeroen G H P VerhoevenKarin BoerMarian C Clahsen-Van GroningenBrenda C M De WinterCarla C BaanDennis A Hesselink

Published in: Therapeutic drug monitoring (2022)

Differences in TAC [CD3] and TAC [CD14] between patients with and without rejection could not be demonstrated. However, further optimization of the cell isolation process is required because a difference in TAC [PBMC] between fresh and cryopreserved cells was observed. These results need to be confirmed in a study with a larger number of patients.

Keyphrases

nk cells
newly diagnosed
induced apoptosis
ejection fraction
liver failure
stem cells
intensive care unit
cell death
cell cycle arrest
peripheral blood
signaling pathway
reactive oxygen species
acute respiratory distress syndrome
umbilical cord
pi k akt
mechanical ventilation