m6 A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization.

Chuandong LangChi YinKaiyuan LinYue LiQing YangZhengquan WuHong DuDong RenYuhu DaiXinsheng Peng

Published in: Clinical and translational medicine (2022)

Our study uncovers a novel molecular mechanism by which the m6 A-induced PCAT6/IGF2BP2/IGF1R axis promotes PCa bone metastasis and tumor growth, suggesting that PCAT6 may serve as a promising prognostic marker and therapeutic target against bone-metastatic PCa.

Keyphrases

prostate cancer
binding protein
bone mineral density
pi k akt
growth hormone
soft tissue
bone loss
bone regeneration
small cell lung cancer
squamous cell carcinoma
postmenopausal women
radical prostatectomy
signaling pathway
oxidative stress
drug induced
cell proliferation