RAS-driven oncogenesis is supported by downstream antioxidant programs.
Jonathan K M LimGabriel LeprivierPoul H SorensenPublished in: Molecular & cellular oncology (2019)
In our recent study, we demonstrated that oncogenic RAS (rat sarcoma)-mediated transformation and tumorigenesis are supported by transcriptional induction of a crucial antioxidant component, SLC7A11 (solute carrier family 7 member 11), otherwise known as XCT, a gene encoding the cystine/glutamate transporter. Our data highlight that this promotes the biosynthesis of glutathione, in turn allowing RAS transformed cells to mitigate tumorigenesis-linked oxidative stress.
Keyphrases
- oxidative stress
- induced apoptosis
- wild type
- transcription factor
- ischemia reperfusion injury
- dna damage
- diabetic rats
- anti inflammatory
- public health
- gene expression
- cell cycle arrest
- electronic health record
- genome wide
- heat shock
- endoplasmic reticulum stress
- copy number
- big data
- cell proliferation
- fluorescent probe
- cell death