To effectively kill microorganisms on scrap facemasks (FMs) surface and provide new material for extracting uranium (U(VI)) from seawater, scrap FMs was treated by N 2 capacitance coupled (CCP) plasma and modified with polyamidoxime (PAO). The obtained PAO/FMs was well characterized and applied as an adsorbent in the extraction of U(VI) from seawater. The effects of environmental conditions on the adsorption capability of PAO/FMs for U(VI) were briefly studied. Results showed that plasma technique can synchronously kill microorganisms and induce acrylonitrile (AN) polymerization on FMs surface. The prepared PAO/FMs presented excellent adsorption capability for U(VI). The experimental results highlighted the application of plasma technique in the management of scrap FMs, and PAO/FMs in the extraction of U(VI) from seawater.