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Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study.

Toby MansellAnne-Louise PonsonbyVania JanuarBoris NovakovicFiona CollierDavid BurgnerPeter VuillerminJoanne RyanRichard Safferynull null
Published in: Clinical epigenetics (2019)
Pre- and perinatal factors impact HIF3A methylation, including pre-eclampsia. This provides evidence that specific pregnancy complications, previously linked to adverse outcomes for both mother and child, impact the infant epigenome in a molecular pathway critical to several vascular and metabolic conditions. Further work is required to understand the mechanisms and clinical relevance, particularly the differing effects of in utero exposure to gestational diabetes or pre-eclampsia.
Keyphrases
  • early life
  • dna methylation
  • genome wide
  • mental health
  • pregnancy outcomes
  • gene expression
  • genome wide identification
  • genome wide analysis