Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+ nucleated red blood cells.
Matthew A BergensGary S PittmanIsabel J B ThompsonMichelle R CampbellXuting WangCathrine HoyoDouglas A BellPublished in: Clinical epigenetics (2019)
Prenatal smoke exposure was highly significantly associated with AHRR methylation in cord blood, CD14+ monocytes, and CD235a+ nRBCs. AHRR methylation levels in nRBCs and nRBC counts had minimal effect on cord blood methylation measurements. However, regression models using estimated nRBCs or actual nRBC counts outperformed those lacking these covariates.