Shear Forces Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia.

Antoine Rauch Annabelle Dupont Mickael Rosa Maximilien Desvages Christina Le Tanno Johan AbdoulMélusine DidelotAlexandre UngRichard RuezEmmanuelle JeanpierreMélanie Daniel Delphine CorseauxHugues SpillemaekerJulien Labreuche Bénédicte Pradines Natacha Rousse Peter J LentingMouhamed D MoussaAndré Vincentelli Jean Claude Bordet Bart Staels Flavien Vincent Cecile V Denis Eric Van Belle Caterina Casari Sophie Susen

Published in: Circulation research (2023)

ECMO-associated shear forces induce GP Ibα shedding and thrombocytopenia due to faster clearance of GP Ibα-negative platelets. Inhibiting GP Ibα shedding could represent an approach to reduce thrombocytopenia during ECMO.

Keyphrases

extracorporeal membrane oxygenation
acute respiratory distress syndrome
respiratory failure
high glucose
signaling pathway
diabetic rats
drug induced
endothelial cells