Infliximab vs. adalimumab in Crohn's disease: results from 327 patients in an Australian and New Zealand observational cohort study.
J D DoeckeF HartnellP BamptonS BellG MahyZ GroverP LewindonL V JonesK SewellK KrishnaprasadR ProsserD MarrJ FischerG R ThomasJ V TehanNik Sheng DingS E CookeK MossA SechiP De CruzR GraftonS J ConnorI C LawranceR B GearryJ M AndrewsG L Radford-Smithnull nullPublished in: Alimentary pharmacology & therapeutics (2016)
In this large, real-life study, we demonstrate infliximab and adalimumab to have similar response characteristics. However, infliximab requires concomitant immunomodulator to achieve optimal maintenance of response comparable to adalimumab monotherapy. The results of this study will assist clinicians in further optimising patient care in their day-to-day clinical practice.