First complete remission favours haploidentical haematopoietic stem cell transplantation with post-transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia.
Tomoyasu JoTomoaki UedaYu AkahoshiTadakazu KondoNaoyuki UchidaMasatsugu TanakaHirohisa NakamaeNoriko DokiShuichi OtaMasashi SawaHiroyuki OhigashiYumiko MaruyamaNobuyuki TakayamaTetsuya NishidaNobuhiro HiramotoYuta KatayamaYoshinobu KandaTatsuo IchinoheYoshiko AtsutaYasuyuki Arainull nullPublished in: British journal of haematology (2024)
To assess the benefits of HLA-haploidentical haematopoietic stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy-haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy-haplo was associated with a significantly higher relapse rate, but lower non-relapse mortality, which results in overall survival and disease-free survival, comparable to those of UCB. Among patients in CR1, PTCy-haplo showed a significantly higher survival than UCB regardless of the CD34 + cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL.
Keyphrases
- stem cell transplantation
- free survival
- high dose
- cord blood
- umbilical cord
- liver failure
- low dose
- mesenchymal stem cells
- end stage renal disease
- cell therapy
- respiratory failure
- chronic kidney disease
- ejection fraction
- newly diagnosed
- drug induced
- machine learning
- peritoneal dialysis
- prognostic factors
- aortic dissection
- single cell
- deep learning
- type diabetes
- intensive care unit
- rheumatoid arthritis
- risk factors
- cardiovascular events
- disease activity
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- ulcerative colitis
- bone marrow
- hematopoietic stem cell