Interleukin-1α deficiency reduces adiposity, glucose intolerance and hepatic de-novo lipogenesis in diet-induced obese mice.

Tal AlmogMichal Kandel KfirHana LevkovichGadi ShlomaiIris BarshackRinke StienstraYaniv LustigAlicia Leikin FrenkelAyelet HarariYoram BujanoverRoni ApteAviv ShaishDror HaratsYehuda Kamari

Published in: BMJ open diabetes research & care (2019)

We demonstrate a novel role of IL-1α in promoting adiposity, obesity-induced glucose intolerance and liver TG accumulation and suggest that IL-1α blockade could be used for treatment of obesity and its metabolic consequences.

Keyphrases

insulin resistance
high fat diet induced
weight gain
metabolic syndrome
weight loss
adipose tissue
type diabetes
skeletal muscle
blood glucose
high glucose
body mass index
replacement therapy
diabetic rats
endothelial cells