Infant RSV immunoprophylaxis changes nasal epithelial DNA methylation at 6 years of age.
Cheng-Jian XuNienke M ScheltemaCancan QiRolf VedderLaura B C KleinElisabeth E NibbelkeCornelis K van der EntLouis J BontGerard H KoppelmanPublished in: Pediatric pulmonology (2021)
The study provides the first proof of concept that RSV immunoprophylaxis during infancy has long-term effects on nasal epigenetic signatures at age 6, relating to host sensory perception, epidermal growth factor receptor signaling, and adaptive immune responses.