SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy.
Anna KovilakathAdolfo Gabriele MauroYolander A ValentineFrank J RaucciMaryam JamilChristiane CarterJeremy ThompsonQun ChenBeutner GiselaYang YueJeremy AllegoodXiaoxin X WangJordan DailTeja DevarakondaKomuraiah MyakalaJolene J WindleMark A SublerDavid MontefuscoBelinda B WillardAli JavaheriTytus BernasSushil K MahataMoshe LeviJinze LiuGeorge A PorterEdward J LesnefskyFadi N SalloumL Ashley CowartPublished in: Circulation (2024)
Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.