The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: a rat model

İnayet Güntürk Cevat Yazıcı Sema Kader Köse Fatma Dağli Bilal Yücel Arzu Hanim Yay

Published in: Turkish journal of medical sciences (2019)

It is suggested that inflammation has a limited effect on cisplatin nephrotoxicity in this experimental design, and, as reflected by decreased BUN and creatinine levels, NAC can be used as an additional therapeutic agent in standard cisplatin treatment protocols.

Keyphrases

oxidative stress
dna damage
ischemia reperfusion injury
diabetic rats
induced apoptosis
transcription factor
drug induced
heat shock
replacement therapy
genome wide analysis