COX-2 pathway is upregulated in ultra-high risk individuals for psychosis.
Cícero A C PereiraAlana C CostaHelena P G JoaquimLeda Leme TalibMartinus Theodorus van de BiltAlexandre A LochWagner F GattazPublished in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2021)
Our findings suggest that overactivation of the COX-2 pathway may be related to an increased risk for psychosis. However, our data do not allow us to draw conclusions related to the cause-effect mechanisms. Future studies should determine whether the levels of the eicosanoids have a predictive value for the transition of UHR to frank psychosis.