Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes.
Maria Loredana MarcovecchioMarco ColomboRaymond Neil DaltonPaul M McKeiguePaul Benitez-AguirreFergus J CameronScott T ChiesaJennifer J CouperMaria E CraigDenis DanemanElizabeth A DavisJohn E DeanfieldKim C DonaghueTimothy W JonesFarid H MahmudSally M MarshallAndrew NeilHelen M ColhounProfessor David Dungernull nullPublished in: Pediatric diabetes (2020)
In this young population with T1D and high rates of hyperfiltration, osteopontin was the most consistent biomarker associated with prospective changes in eGFR. FGF-23 was associated with eGFR increases, whereas trefoil factor-3, cystatin C, and B2M were associated with baseline eGFR.