Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children.

Sandra HodgeMatthew MacowanHong LiuRhys HamonAlice C-H ChenJulie M MarchantSusan J PizzuttoJohn W UphamAnne B Chang

Published in: Pediatric pulmonology (2020)

Children with PBB and BE share similar S1P-associated gene expression profiles. AM phagocytic dysfunction and inflammation in these children may occur due to dysregulated S1P signaling.

Keyphrases

young adults
oxidative stress
induced apoptosis
cystic fibrosis
genome wide
dna methylation
copy number
signaling pathway
cell proliferation
cell death
endoplasmic reticulum stress
human health