Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors.
Paola CuomoChiara MedagliaIvana AlloccaAngela Michela Immacolata MontoneFabrizia GuerraSerena CabaroErnesto MolloDaniela ElettoMarina PapaianniRosanna CapparelliPublished in: International journal of molecular sciences (2021)
The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors that play key roles in both the regulation and the resolution of the innate inflammatory response. Specifically, we investigated, in vitro, whether Caulerpin-a bis-indole alkaloid isolated from algae of the genus Caulerpa-could act as a molecular antagonist scaffold of FPRs. We showed that Caulerpin significantly reduces the immune response against Hp culture filtrate, by reverting the FPR2-related signaling cascade and thus counteracting the inflammatory reaction triggered by Hp peptide Hp(2-20). Our study suggests Caulerpin to be a promising therapeutic or adjuvant agent for the attenuation of inflammation triggered by Hp infection, as well as its related adverse clinical outcomes.
Keyphrases
- helicobacter pylori
- immune response
- oxidative stress
- helicobacter pylori infection
- inflammatory response
- diabetic rats
- dendritic cells
- toll like receptor
- drug induced
- early stage
- signaling pathway
- emergency department
- ionic liquid
- high glucose
- lipopolysaccharide induced
- radiation therapy
- drug delivery
- lps induced
- radiation induced
- bioinformatics analysis
- atomic force microscopy