FBP1 induced by β-elemene enhances the sensitivity of gefitinib in lung cancer.

Jian LiPing DaiJing SunWenyan YuWei HanKaichun Li

Published in: Thoracic cancer (2022)

Our research indicated that β-elemene suppressed proliferation and enhanced sensitivity to gefitinib by inducing apoptosis through the FBP1/STAT3 axis in gefitinib-resistant lung cancer cells.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
oxidative stress
endoplasmic reticulum stress
signaling pathway
tyrosine kinase
cell death
cell cycle arrest