High-sensitivity detection of Mycobacterium tuberculosis DNA in tongue swab samples.

Alaina M OlsonRachel C WoodKris M WeigelAlexander J YanKatherine A LochnerRane B DragovichAngelique K Luabeya Paul YagerMark HatherillGerard A Cangelosi

Published in: medRxiv : the preprint server for health sciences (2024)

Improved testing for tuberculosis (TB) is needed. Using a more accessible sample type than sputum may enable the detection of more cases, but it is critical that alternative samples be tested appropriately. Here, we describe two new, highly accurate methods for testing tongue swabs for TB DNA.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
circulating tumor
loop mediated isothermal amplification
cell free
single molecule
real time pcr
label free
emergency department
high resolution
nucleic acid
cystic fibrosis
circulating tumor cells
hiv aids
drug induced