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Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors.

Anvita KomarlaSuzanne DufresneChristina G Towers
Published in: Endocrine reviews (2023)
Autophagy plays a complex role in several cancer types, including endocrine-dependent cancers, by fueling cellular metabolism and clearing damaged substrates. This conserved recycling process has a dual function across tumor types where it can be tumor suppressive at early stages but tumor promotional in established disease. This review highlights the controversial roles of autophagy in endocrine-dependent tumors regarding cancer initiation, tumorigenesis, metastasis, and treatment response. We summarize clinical trial results thus far and highlight the need for additional mechanistic, pre-clinical and clinical studies in endocrine-dependent tumors particularly in breast cancer and prostate cancer.
Keyphrases
  • prostate cancer
  • cell death
  • clinical trial
  • papillary thyroid
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • squamous cell
  • childhood cancer
  • transcription factor
  • lymph node metastasis
  • phase iii