Concordant acute myeloblastic leukemia in identical twins treated with allogeneic transplantation from a younger HLA-identical sibling following a single apheresis procedure.
Yajaira Valentine Jimenez-AntolinezElias Eugenio Gonzalez-LopezIleana Yazmín Velasco RuizMarcela Cantu-MorenoGuillermo José Ruiz ArgüellesOscar Gonzalez-LlanoPublished in: International journal of hematologic oncology (2020)
A concordant leukemia is that which occurs in a pair of monozygotic twins; a similar genetic background suggests an in utero monoclonal origin. We present the case of a pair of monozygotic infants with concordant acute myeloid leukemia who underwent a peripheral blood hematopoietic stem-cell transplant (HSCT) from a single, younger human leukocyte antigen-identical sibling donor, using a fractioned graft collected during only one apheresis procedure. Twin A relapsed at +456 and received a second haploidentical HSCT from his father, twin B has been in complete remission since the first HSCT. Both children are in complete remission and with negative minimal residual disease at +900 (after second transplant) and +1488, respectively.
Keyphrases
- hematopoietic stem cell
- acute myeloid leukemia
- peripheral blood
- allogeneic hematopoietic stem cell transplantation
- endothelial cells
- disease activity
- minimally invasive
- liver failure
- gestational age
- bone marrow
- ulcerative colitis
- young adults
- multiple myeloma
- respiratory failure
- induced pluripotent stem cells
- genome wide
- rheumatoid arthritis
- aortic dissection
- drug induced
- stem cells
- gene expression
- dna methylation
- hepatitis b virus
- mesenchymal stem cells
- low dose