PyBox-La(OTf) 3 -Catalyzed Enantioselective Diels-Alder Cycloadditions of 2-Alkenoylpyridines with Cyclopentadiene.

Hao WeiYujie ZhangSanlin JinYing YuNing ChenJiaxi XuZhanhui Yang

Published in: Molecules (Basel, Switzerland) (2024)

The PyBox-La(OTf) 3 -catalyzed enantioselective Diels-Alder cycloaddition of 2-alk-2-enoylpyridines with cyclopentadiene is realized, producing enantiopure disubstituted norbornenes, which possess four contiguous stereocenters and are biologically relevant structures in up to 92:8 dr and 99:1 er.

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