Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.

Yalan LeiJin XuMingming XiaoDi WuHe XuJing YangXiaoqi MaoHaoqi PanXian-Jun Yu Xianjun Yu

Published in: British journal of cancer (2024)

Pirfenidone may alter the pancreatic milieu and alleviate fibrosis through the regulation of tumour-stroma interactions via the TGM2/NF-kB/PDGFB signalling pathway, suggesting potential therapeutic benefits in PDAC management.

Keyphrases

idiopathic pulmonary fibrosis
pulmonary fibrosis
signaling pathway
lps induced
oxidative stress
liver fibrosis
nuclear factor
mouse model
inflammatory response
immune response
toll like receptor