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Asymmetric Synthesis of the Functionalized A/E-Ring Fragment of C 18 -Diterpenoid Alkaloids.

Fei LuYu ShaoShulin YanDingyi YangHao SongDan ZhangXiao-Yu LiuYong Qin
Published in: The Journal of organic chemistry (2024)
A new asymmetric synthesis of the A/E-ring fragment of C 18 -diterpenoid alkaloids is described. The crucial contiguous stereogenic centers at C4, C5, and C11 were established through an asymmetric Michael addition/allylation sequence. The unique azabicyclo[3.3.1]nonane motif (A/E rings) was assembled by employing ring-closing metathesis and Mitsunobu reaction as key strategies.
Keyphrases
  • solid state
  • quantum dots
  • mass spectrometry
  • high resolution
  • molecularly imprinted
  • liquid chromatography