Incorporation of second-tier tests and secondary biomarkers to improve positive predictive value (PPV) rate in newborn metabolic screening program.

Sarang YounesiBahareh YazdaniMohammad Mahdi Taheri AminPourandokht SaadatiSoudabeh JamaliMohammad-Hossein ModarresiShahram SavadSaloomeh AmidiHomayoun RazaviSeyedeh Morvarid Neishabouri

Published in: Journal of clinical laboratory analysis (2022)

This study showed a high incidence of metabolic disease due to a high rate of consanguineous marriages in Iran and indicated that incorporation of second-tier tests and secondary biomarkers improves PPV of neonatal screening programs.

Keyphrases

risk factors
quality improvement