Prevalence of NUDT15 genetic variants and incidence of thiopurine-induced leukopenia in Inflammatory Bowel Disease: A systematic review and meta-analysis.

Natalie Yu Danujan SriranganathanGareth J WalkerAleksejs SazonovsHelen WildingChristopher RobertsNicholas A KennedyTariq AhmadRay K BoyapatiNik Sheng DingJonathan P Segal

Published in: Journal of Crohn's & colitis (2023)

NUDT15 variants are common and strongly predict TIL in IBD patients. Pre-treatment NUDT15 genotyping should be considered particularly in Asian populations to guide thiopurine dosing and prevent myelotoxicity.

Keyphrases

end stage renal disease
risk factors
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported outcomes
gene expression
copy number
diabetic rats
dna methylation
oxidative stress
drug induced