The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers.
Maryse CloutierJean-Simon FortinJacques ThibodeauPublished in: BMC immunology (2021)
Altogether, our data show that trimerization of Ii through either TM or TRIM sustains nonameric complex formation with MHCII molecules.