Focal impaired awareness seizures in a rodent model: a functional anatomy.
Nadia AdoteviJaideep KapurPublished in: Epilepsia open (2021)
This study highlights neuronal circuits preferentially activated during a focal awareness impaired seizure in a rodent model. Many of the seizure-activated neuronal circuits are critical modulators of memory consolidation and long-term stress/depression response. The hijack of these memory and depression regulatory systems by a focal seizure could account for the frequent reports of comorbidities such as memory impairment and depression in many TLE patients.
Keyphrases
- depressive symptoms
- working memory
- temporal lobe epilepsy
- sleep quality
- end stage renal disease
- ejection fraction
- newly diagnosed
- small molecule
- peritoneal dialysis
- prognostic factors
- transcription factor
- emergency department
- patient reported outcomes
- cerebral ischemia
- patient reported
- electronic health record
- subarachnoid hemorrhage