Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates.
Minyoung KwakGulsun ErdagKatie M LeickStefan BekiranovVictor H EngelhardCraig L SlingluffPublished in: Journal of translational medicine (2021)
These data do not support our hypothesis that each immune cell subset is uniquely associated with specific ICH genes. Instead, a larger set of ICH genes identifies melanomas with concordant infiltration of B-cell and T-cell lineages, while CD163+ M2-macrophage infiltration suggesting alternate mechanisms for their recruitment. Future studies should explore the extent ICH gene signature contributes to tertiary lymphoid structures or cross-talk between homing pathways.
Keyphrases
- genome wide
- genome wide identification
- dna methylation
- copy number
- endothelial cells
- peripheral blood
- genome wide analysis
- transcription factor
- adipose tissue
- single cell
- bone marrow
- nk cells
- electronic health record
- cell therapy
- stem cells
- dendritic cells
- high resolution
- induced pluripotent stem cells
- gene expression
- mass spectrometry
- mesenchymal stem cells
- case control
- data analysis