Mouse model of ocular hypertension with retinal ganglion cell degeneration.

Ryo MukaiDong Ho ParkYoko OkunukiEiichi HasegawaGarrett KlokmanClifford B KimAnitha KrishnanMeredith Gregory-KsanderDeeba HusainJoan W MillerKip M Connor

Published in: PloS one (2019)

These results suggest that sustained IOP elevation causes more RGC damage in the periphery than in the midperiphery of the retina. This model yields significant and reproducible RGC degeneration.

Keyphrases

mouse model
blood pressure
optic nerve
single cell
cell therapy
oxidative stress
diabetic retinopathy
optical coherence tomography