Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia-reperfusion injury.

Weijie YangXiuxing LeiFengying LiuXin SuiYi YangZhenyu XiaoZiqi CuiYangyang SunJun YangXinyi YangXueyang LinZhenghao BaoWeidong LiYingkai MaYongan WangYuan Luo

Published in: Journal of translational medicine (2024)

Our study demonstrated that meldonium shows a neuroprotective function during CIRI by preserving the mitochondrial function, thus prevented neurons from apoptosis.

Keyphrases

cerebral ischemia
ischemia reperfusion injury
oxidative stress
subarachnoid hemorrhage
cell death
brain injury
endoplasmic reticulum stress
blood brain barrier
spinal cord
cell cycle arrest
reactive oxygen species
cell proliferation
risk assessment
signaling pathway
endoplasmic reticulum
pi k akt