Evaluating the efficacy of the anticancer drug cetuximab by atomic force microscopy.
Qingrong ZhangYan ShiHaijiao XuLulu ZhouHongda WangJunguang JiangMingjun CaiYuping ShanPublished in: RSC advances (2018)
Cetuximab is a monoclonal antibody that binds to the epidermal growth factor receptor, which is important in the growth of many cancers. However, the biophysical characteristics of cetuximab as an anti-cancer drug remain elusive. In this study, we adopted atomic force microscopy to measure the mechanical properties of cancer cells following cetuximab treatment and the biomechanical properties of cetuximab and epidermal growth factor receptor interactions. Atomic force microscopy can be implemented as a platform for further investigations that target the cellular stiffness and affinity of ligand-receptor as a therapeutic choice.
Keyphrases
- atomic force microscopy
- epidermal growth factor receptor
- metastatic colorectal cancer
- high speed
- tyrosine kinase
- advanced non small cell lung cancer
- single molecule
- locally advanced
- wild type
- monoclonal antibody
- squamous cell carcinoma
- rectal cancer
- radiation therapy
- young adults
- combination therapy
- mass spectrometry