Ingestion of a natural mineral-rich water in an animal model of metabolic syndrome: effects in insulin signalling and endoplasmic reticulum stress.
Cidália D PereiraEmanuel PassosMilton SeveroIsabel VitóXiaogang WenFátima CarneiroPedro GomesRosário MonteiroMaria João MartinsPublished in: Hormone molecular biology and clinical investigation (2017)
Mineral-rich water modulation of fructose-induced effects on insulin signalling and ER homeostasis matches the better metabolic profile previously reported. Increased p-ERK/ERK, adding to decreased IRE1α activation, and increased unspliced-XBP1 and lipid area may protect against oxidative stress and IR development in FRUCTMIN.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- type diabetes
- signaling pathway
- metabolic syndrome
- oxidative stress
- diabetic rats
- pi k akt
- cell proliferation
- glycemic control
- high glucose
- dna damage
- insulin resistance
- endoplasmic reticulum
- uric acid
- drug induced
- cardiovascular disease
- adipose tissue
- endothelial cells
- skeletal muscle
- heat stress
- organic matter