Increased let-7d-5p in non-alcoholic fatty liver promotes insulin resistance and is a potential blood biomarker for diagnosis.

Jorge Infante-Menéndez Andrea R López-PastorTamara González-IllanesPaula González-LópezRaquel Huertas-LárezEsther ReyÁgueda González-Rodríguez Carmelo García-MonzónNikita P PatilMelina Vega de CénigaAaron B BakerAlmudena Gómez-Hernández Oscar Escribano

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

Our results highlight the emerging role of let-7d-5p as a potential therapeutic target for NAFLD since its overexpression impairs hepatic insulin signalling, and also, as a novel non-invasive biomarker for NAFLD diagnosis.

Keyphrases

insulin resistance
type diabetes
cell proliferation
liver injury
adipose tissue
high fat diet
transcription factor
polycystic ovary syndrome
glycemic control
drug induced
high fat diet induced