Au-Doped Ag2 Te Quantum Dots with Bright NIR-IIb Fluorescence for In Situ Monitoring of Angiogenesis and Arteriogenesis in a Hindlimb Ischemic Model.
Hongchao YangHaoying HuangXiang MaYejun ZhangXiaohu YangMengxuan YuZiqiang SunChunyan LiFeng WuQiangbin WangPublished in: Advanced materials (Deerfield Beach, Fla.) (2021)
Fluorescence located in 1500-1700 nm (denoted as the near-infrared IIb window, NIR-IIb) has drawn great interest for bioimaging, owing to its ultrahigh tissue penetration depth and spatiotemporal resolution. Therefore, NIR-IIb fluorescent probes with high photoluminescence quantum yield (PLQY) and stability along with high biocompatibility are urgently pursued. Herein, a novel NIR-IIb fluorescent probe of Au-doped Ag2 Te (Au:Ag2 Te) quantum dots (QDs) is developed via a facile cation exchange method. The Au dopant concentration in the Ag2 Te QDs is tunable from 0% to 10% by controlling the ratio of supplied Au precursor to Ag2 Te QDs, resulting in a wide range of PL emission in the NIR-IIb window and a much-enhanced PL intensity. After surface modification, the Au:Ag2 Te QDs possess bright NIR-IIb emission, high colloidal stability and photostability, and decent biocompatibility. Further, in vivo monitoring of the process of angiogenesis and arteriogenesis in an ischemic hindlimb is successfully performed.
Keyphrases
- quantum dots
- sensitive detection
- fluorescent probe
- living cells
- energy transfer
- photodynamic therapy
- fluorescence imaging
- drug release
- reduced graphene oxide
- single molecule
- visible light
- vascular endothelial growth factor
- endothelial cells
- small molecule
- ischemia reperfusion injury
- ionic liquid
- optical coherence tomography
- drug delivery
- light emitting
- gold nanoparticles
- tissue engineering
- highly efficient
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage